Identifying the critical need to invest in infrastructure and establish healthcare facilities to advance public health and improve quality of life, AGBU donors established funds to support these efforts. Within a short period of time, AGBU established the Tarouhi Hagopian Maternity Ward (including a school for midwives), the Marie Noubar Eye Clinic, and the Aved Sarkis Rabies Clinic in Yerevan.
AGBU also established its first office in Armenia during this time with an apartment building for professors of the University of Yerevan and other intellectuals called "Parekordzagan Doon" on Apovian Street. In a continued effort to improve the livelihood of the population AGBU also funded numerous educational projects.
Proving to the local officials in that AGBU was a valuable partner in humanitarian projects, such as the establishment of the Marie Noubar Eye Clinic, the Tarouhi Hagopian Maternity Ward and the Aved Sarkis Rabies Clinic, the Soviet authorities granted AGBU lands to build model farms and agricultural schools in Yeghvart and Dalma. Similar investments continued in various neighborhoods with the most ambitious project being the establishment of Nubarashen, an entirely new village outside of Yerevan conceived by Boghos Nubar and designed by Alexander Tasmanian to welcome new waves of immigration to Armenia. Construction of the homes and factories, the school, the hospital, and the theater of Nubarashen began in 1931. By 1936, AGBU had invested $417,000 in the project, but was forced to abandon progress a year later at the height of the Stalinist purges.